IBD or Inflammatory Bowel Disease affects as many as 4 million people around the world. It has a productivity loss of nearly a billion dollars associated with. Those who suffer from IBD often have the following symptoms as well as other issues.
- Weight loss
- Abdominal pain
- Rectal bleeding
- Skin and eye irritations
There are many conventional and alternative treatments that are used to treat IBD and we will look at these treatments a little, right now we’ll look at the rols of HGH therapy in treating IBD. The use of HGH in the treatment of IBD has had some studies. HGH has been approved for use in children and adults in a handful of condition; however, doctors often prescribe HGH therapy for off label, especially in anti aging purposes. HGH is not approved by the FDA as a treatment of inflammatory bowel disease.
Study of HGH Therapy for IBD
- While HGH was effective in adults with IBD in a small, randomized study, to date it has not been studied in a large controlled trial.
- It is likely gastroenterologists or internists will meet patients with IBD who may be shown improvement after taking d HGH for anti aging.
- HGH therapy in IBD patients has been used primarily for the treatment of growth delay in children who suffer from IBD, with variable effect. Children with growth delay and IBD is caused numerous factors, including activity of inflammation, including nutritional status, genotype, and disease severity all of which may lead to a GH resistant state. There has been evidence in both adults and children suggesting that the GH/IGF-1 axis is functionally impaired in patients with IBD. In particular, IBD is characterized by a state of GH resistance in which there is normal GH secretion but impaired induction of GH target genes.GH replacement therefore, may be beneficial by circulating GH and IGF-1 levels. Furthermore, GH and other trophic factors act upon epithelial cells, mesenchymal cells, and intestinal immune cells to promote improved mucosal integrity, mucosal healing, and modulation of inflammation.
- There is experimental evidence supporting the use of HGH therapy for the IBD treatment. Studies in rats with chemically induced colitis have shown that HGH therapy promotes intestinal mucosal repair, and HGH has also been shown to reduce intestinal fibrosis and stimulate expression of anti-fibrinogenic signaling molecules.
- In a placebo-controlled pilot study of 37 adult patients with active CD (Crohn’s Disease), HGH therapy given concurrently with a high protein diet significantly improved CD Activity Index (CDAI) scores and reduced the need for additional medications. There was a mean decrease of 143 points on the CDAI from baseline values in HGH-treated subjects, as compared with a 19 point drop in the placebo group.
- Several clinical trials have also shown that HGH has valuable anabolic effects in patients with short bowel syndrome (SBS), many of whom had CD (Crohn’s Disease) as an indication for bowel resection. A meta-analysis of 13 trials on 258 patients conducted on the safety and efficacy of growth hormone with a modified high-carbohydrate, low-fat diet in patients with SBS showed a positive treatment effect on body weight, stool output, lean body mass, absorption of carbohydrates, absorption of nitrogen, absorption of D-xylose, and time off total parenteral nutrition in these patients.
Medications Used In Treatment of IBD
There are a number of medications that are used in the treatment of IBD. Some treatments are more effective than others, but results vary depending on individual. While we mention these treatments you may want to discuss trying HGH Therapy with your doctor. This may be a better option.
- Sulfasalazine – is known as a 5-aminosalicylate acid (5-ASA) compound, a combination of two drugs (sulfapyridine and an aspirin-like compound [5-ASA]) that reduces inflammation in the colon and helps maintain remission.
- Corticosteroids – are similar to cortisol, a steroid the body produces in the adrenal gland. This fast-acting drug reduces inflammation and is usually prescribed to curb an acute flare-up. Azathioprine (Imuran), 6-mercaptopurine (Purinethol, 6-MP) and cyclosporine A (Sandimmune, Neoral)—a class of drugs that are used to inhibit the immune system. IBD is an autoimmune disease, and while suppressing the immune system may lessen symptoms, it also leaves the body more susceptible to infection.
- Methotrexate – is most often given by injection and tends to induce remission in eight to 10 weeks.
- Infliximab – is stops tumor necrosis factor alpha from being used by the body.
HGH therapy for IBD may improve IBD activity but it needs further study and is not currently approved for the treatment of IBD. Talk to your doctor if you would like to try HGH therapy.