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Resveratrol Analyzed: Does it Live Up To The Hype?

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Guide to Resveratrol

Red Grapes Nowadays, all anyone in the medical, cosmetic, and healthcare industries can talk about is the newest panacea formula to hit the mainstream: Resveratrol. If you haven't been keeping abreast with the latest scientific studies then you've likely overlooked the culmination of all the modern reports on this miracle medicine. If you have been keeping tabs and you're already aching to get some Resveratrol "magic" yourself, then you've likely seen the latest articles and columns found in publications like CNN and the Mayo site or watched the interviews from shows like Oprah and 60 Minutes.

 History and Timeline of Resveratrol Research

Resveratrol, otherwise known as trans-Resveratrol, is a biologically produced Phytoalexin created by certain plant life whenever they're assaulted by pathogens like fungi or bacteria. Resveratrol has been successfully synthesized by scientists and is currently available as a nutritional supplement procured mainly from Japanese knotweed. It is also found in red grape skin and is one of the many ingredients of red wine.

In certain experiments involving rats and mice as test subjects, more than a few beneficial Resveratrol effects involving cardiovascular/blood sugar/inflammation/cancer management has been observed. Moreover, in the only positive human trial for the drug thus far, sizeable doses of resveratrol (about 3 to 5 grams worth) in a propriety product has shown to appreciably decrease blood sugar content in people.

  • Cancer Application: In 1997, a scientist named Jang and his team of researchers reported that using Resveratrol as a topical agent can prevent skin cancer progression in mice treated with a carcinogen. Also, there have been a multitude of reports concerning the anti-cancer ability of Resveratrol in other animal species. Clinical trials are presently being conducted in regards to resveratrol effects on melanoma and colon cancer in humans.
  • Lifespan Increase in Yeast, Fruit Flies, and Worms: In 2003, the groups of Sinclair and Howitz disclosed to the journal "Nature" that Resveratrol significantly extends the lifespan of a certain species of yeast (Saccharomyces cerevisiae). Later tests by the Sinclair group demonstrated Resveratrol's ability to also lengthen the lifespan of certain species of fruit fly (Drosophila melanogaster) and worm (Caenorhabditis elegans).
  • Lifespan Increase in Short-Lived Fish: In 2006, the inevitable resveratrol experiments on non-invertebrate animals led to the first positive result of supplementation on a vertebrate care of several Italian scientists. The authors used a short-lived fish (Nothobranchius furzeri) that typically lives for nine weeks, and were able to increase its lifespan by 56%. Compared to the control fish, the supplemented fish learned to avoid painful stimulus quicker and had higher swimming-related activity. Because of the slight increase in death of young fish caused by resveratrol, the Italian researchers conjectured that it was the fish's weak toxic action that activated its defense mechanisms and caused the lifespan prolongation.
  • Duplicated Results and Mice Experimentation: In 2007, a different team of researchers were able to duplicate Sinclair's earlier experiments with Caenorhabditis elegans, but yet another group of researchers failed to achieve consistent increases in lifespan of either species of worm or fruit fly. Later in the same year, Sinclair announced that resveratrol offset the harmful effects of high-fat diet in mice, which could potentially prove useful in counteracting obesity in humans in the near future. The mice's diet was worsened by adding coconut oil to their food; the increase resulted in a 60% rise of energy from fat, which made the mice eat about 30% more calories than the control mice that were on a customary diet. A joint study by another group of researchers and the Sinclair group demonstrated that resveratrol therapy had a variety of helpful outcomes in elderly mice but wasn't able to increase the lifespan of fattened mice when the treatment is commenced in midli

Most Significant Resveratrol Benefits

Resveratrol is believed by many experts and healthcare professionals to assist in three major health issues: neurodegenerative sicknesses, cancer prevention, and life extension or aging delay. The chemical is also known to improve overall health and has many other medical benefits to boot. Here are all five benefits presented in further detail:

  • Life Extension: Resveratrol was first documented in 2006 to successfully decrease the physical symptoms of aging and significantly increase life outlook. The formula was considered an anti-aging agent after Italian scientists concluded that, when taken at a young age, it produced a rise in life outlook. Further studies in the last three years have also come up with the same conclusion, thus solidifying Resveratrol's properties when it comes to diminishing the physical manifestation of aging.
  • Cancer Prevention: As mentioned earlier, experts have reported way back in 1997 that Resveratrol is a viable method in preventing cancer. The basic conclusion experts agree upon about Resveratrol is that it can assist in hampering cancer formation when in contact with a tumor and the like. To be more specific, Resveratrol animal tests on stomach and skin cancers have proven to be successful, or at the very least promising.
  • Neurodegenerative Sickness Therapy: Just last year, a Weill Medical School study at Cornell showed that Resveratrol can assist in decreasing plaque formation in the brain. This implies beneficial applications in the realm of Alzheimer's disease treatment and therapy for many other neurodegenerative sicknesses.
  • Healthier Way of Life: To the computer savvy people out there, Resveratrol can be compared to the "defragment" function of your computer. It basically helps make your body become healthier and more efficient at maintaining itself, hence its life-prolonging abilities. By taking regular doses of this supplement, you'll be able to prevent getting health problems before they even occur.
  • A Panacea in Every Sense of the Word: A researcher who helped perform tests on resveratrol's efficacy once claimed that he and his team may have found a true cure-all drug. With the right administration and with the correct complement of medicines, the substance could indeed enable cures for any ailments in the body without harming uninfected or innocent cells.

Pharmacokinetics and Proper Dosage Of Resveratrol 

The most effective method of dosing humans with Resveratrol appears to be buccal delivery; i.e., complete absorption of the chemical through the inside of a person's mouth without swallowing. When one milligram of the chemical in a fifty milliliter solution was held inside the mouth of a test subject for one minute before ingestion, free resveratrol amounting to 37 nanograms per milliliter was measured in his blood just a couple of minutes later. In pill form, you need to take about 250 milligrams worth in order to get the same level of unchanged Resveratrol in your blood plasma. About 70% of Resveratrol is absorbed when administered orally in pill form. However, the agent's oral bioavailability is rather low because it is easily metabolized in your liver and intestines into two conjugated forms: sulfonate and glucuronate. Only trace amounts (below five nanograms per milliliter) of unaltered Resveratrol can be found in the bloodstream after a mere 25 milligram dose.

 On that note, here are the three different possible resveratrol dosages in pill form:

  • Low Resveratrol Dosage: Ranges from 100 to 500 milligrams taken daily.
  • Medium Resveratrol Dosage: Ranges from 500 to 1,500 milligrams taken daily.
  • High Resveratrol Dosage: Anywhere above 1,500 milligrams taken daily.

 These dosages are rather controversial when discussed by different experts and medical professionals. How much of a given Resveratrol supplement should a person take is best left in the hands of your designated healthcare specialist or physician; this is because there are many other factors you need to consider when talking about proper dosage, so nobody knows what's the right dose for you save for your doctor.

Also remember that it's essential for you to let your doctor know about your medical history or allergies to specific drugs in order to avoid mixing Resveratrol with anything that could cause you harmful side effects.

The Future of Resveratrol

This naturally occurring substance is truly making the headlines nowadays. Provided that it lives up to its potential, it could very well prove to be the discovery that changes the course of medical research forever. Truly, ever since test results showed Resveratrol's huge impact on the human body and human health in general, scientists have been working around the clock for other possible applications in which the beneficial supplement can be used on.

 At this point, many corporations are scrambling to create a number of prescription products containing significant traces of the special substance. Many people believe that the discovery of Resveratrol's health benefits is mankind's most important innovation since the invention of the telephone or even the Internet. In addition, future research will probably tackle key medical issues like stroke, heart disease, and so on based on their impending findings concerning Resveratrol's therapeutic properties.



HGH With Resveratrol













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